Tetrahedron Letters p. 6971 - 6974 (2006)
Update date:2022-07-30
Topics:
Montagnat, Oliver D.
Lessene, Guillaume
Hughes, Andrew B.
A series of orthogonally protected 1,4-disubstituted-1,2,3-triazoles were prepared from the corresponding alkynols and trialkylsilyl-propargyl azides via 1,3-dipolar cycloaddition. These cycloadducts were selectively deprotected and extended in a stepwise fashion via further 'click' reactions to form oligomeric peptidomimetic compounds. This methodology gives access to triazole-based peptidomimetics in a controlled fashion and lays the foundation for a fragment-based approach to drug discovery.
View MoreTAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road,Taixing City ,Jiangsu , China
Hubei ShiNan Pharmaceutical Chemical co., Ltd.(expird)
Contact:+86-13554447107
Address:Wuhan HongShanOu wu no road 378 future residence building 1 unit 14 layer no. 1401 A
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Chengdu ZY Biochemical Technology Co., LTD
Contact:0086-28-88680086
Address:170 Qingpu Road, Shouan Town, Pujiang County
Contact:Tel:+86-29-88764861 Fax:+86-29-88764861
Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Doi:10.1016/S0040-4039(00)72778-X
(1968)Doi:10.1016/S0040-4020(98)00271-3
(1998)Doi:10.1055/s-0031-1299744
(2012)Doi:10.1016/j.tetasy.2006.09.026
(2006)Doi:10.1021/ja9806581
(1998)Doi:10.1021/ja01024a052
(1968)