Tetrahedron Letters p. 6971 - 6974 (2006)
Update date:2022-07-30
Topics:
Montagnat, Oliver D.
Lessene, Guillaume
Hughes, Andrew B.
A series of orthogonally protected 1,4-disubstituted-1,2,3-triazoles were prepared from the corresponding alkynols and trialkylsilyl-propargyl azides via 1,3-dipolar cycloaddition. These cycloadducts were selectively deprotected and extended in a stepwise fashion via further 'click' reactions to form oligomeric peptidomimetic compounds. This methodology gives access to triazole-based peptidomimetics in a controlled fashion and lays the foundation for a fragment-based approach to drug discovery.
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