Dihydroretinoic acids and their derivatives. Synthesis and biological activity

DOI: 10.1021/jm00217a011

Source and publish data:

Journal of Medicinal Chemistry p. 918 - 925 (1977)

Update date:2022-08-04

Topics:

Authors:

Pawson Pawson

Cheung Cheung

Han Han

Trown Trown

Buck Buck

Hansen Hansen

Bollag Bollag

Ineichen

Pleil Pleil

Rueegg Rueegg

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00217a011

The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test and in vitro in two vitamin A deficient assays. The activity observed for 1a, 1c, and 2a in the former test was partially retained in the dihydro derivatives 4b, 4c, and 6b. Similar results were found in the in vitro assays.

Full text of DOI:10.1021/jm00217a011

Products guided by the article

Product name:Benzene, 2-chloro-1-methoxy-3,5-dimethyl-

Cas No:62924-32-7

R&D Labs maybe for 62924-32-7

Xi'an Yuri Solar Co., Ltd

website:https://www.yurisolar.com/en

Contact:86--18092602675

Address:No. 560, East Hangtian Road, Xi'an, China
Airsea(Taizhou) Pharmaceutical Limited(expird)

Contact:+86-576-88057622

Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Shanghai ZaiQi Bio-Tech Co., Ltd.,

Contact:+86-21-5482 4098

Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province

Relevant to this article

Synthesis of stable isotope-labeled precursors for the biosyntheses of capsaicinoids, capsinoids, and capsiconinoids

Doi:10.1271/bbb.110187
(2011)
Intramolecular Nucleophilic Substitution by Phosphinate and Thiophosphinate Anions: Relative Rates of Formation of Five- and Six-membered Rings

Doi:10.1039/c39950000083
(1995)
Synthesis of Carbapenems Containing Peptidoglycan Mimetics and Inhibition of the Cross-Linking Activity of a Transpeptidase of l,d Specificity

Doi:10.1002/chem.202004831
(2021)
SUCRES ACETYLENIQUES HETEROSUBSTITUES SUR LA TRIPLE LIAISON

Doi:10.1016/S0008-6215(00)80850-2
(1981)
Bioinspired Syntheses of the Pyridoacridine Marine Alkaloids Demethyldeoxyamphimedine, Deoxyamphimedine, and Amphimedine

Doi:10.1021/acs.joc.5b02312
(2016)
The Regioselective Synthesis of o -Nitrobenzyl DOPA Derivatives

Doi:10.1055/s-0036-1588766
(2017)

Article Doi