Bioorganic and Medicinal Chemistry Letters p. 1413 - 1418 (1998)
Update date:2022-08-04
Topics:
Campiani, Giuseppe
Kozikowski, Alan P.
Wang, Shaomeng
Ming, Liu
Nacci, Vito
Saxena, Ashima
Doctor, Bhupendra P.
Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. From the modeling studies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridging huperzine with Tyr 130 and Glu 199 of AChE. The synthesis of these materials by use of a palladium catalyzed bicycloannulation strategy is detailed together with the results of AChE inhibition assays.
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