Synthesis, β-adrenergi activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2',4',5'-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

Article abstract of DOI:10.1021/jm00177a027

A positional isomer of trimetoquinol (1), 1-(2',4'5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (3), was synthesized and found to possess less β-adrenergic activity than 1 in isolated guinea pig atrial and tracheal preparations. the an