Helvetica Chimica Acta p. 1207 - 1214 (1995)
Update date:2022-07-29
Topics:
Schvartzapel
Fichera
Esteva
Rodriguez
Gros
Several compounds, structurally related to the insect-growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood-bank sterilization or Chagas'-disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity.
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