Bioorganic and Medicinal Chemistry Letters p. 1775 - 1779 (2006)
Update date:2022-07-29
Topics:
Fraley, Mark E.
Garbaccio, Robert M.
Arrington, Kenneth L.
Hoffman, William F.
Tasber, Edward S.
Coleman, Paul J.
Buser, Carolyn A.
Walsh, Eileen S.
Hamilton, Kelly
Fernandes, Christine
Schaber, Michael D.
Lobell, Robert B.
Tao, Weikang
South, Victoria J.
Yan, Youwei
Kuo, Lawrence C.
Prueksaritanont, Thomayant
Shu, Cathy
Torrent, Maricel
Heimbrook, David C.
Kohl, Nancy E.
Huber, Hans E.
Hartman, George D.
The evolution of 2,4-diaryl-2,5-dihydropyrroles as inhibitors of KSP is described. Introduction of basic amide and urea moieties to the dihydropyrrole nucleus enhanced potency and aqueous solubility, simultaneously, and provided compounds that caused mito
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