Journal of Pharmaceutical Sciences p. 887 - 889 (1977)
Update date:2022-08-05
Topics:
Agrawal
Parmar
Dwivedi
Harbison
5-(4-Aminophenoxylmethyl)-2-oxazolidinethiones were synthesized by the cyclization of 1-(4-aminophenoxy)-3-amino-2-propanol in the presence of potassium hydroxide and carbon disulfide. This oxazolidinethione, on reaction with suitable isothiocyanates, yielded 5-[4-(substituted thiocarbamido)phenoxymethyl] -2-oxazolidinethiones. These compounds antagonized the uterotropic effects of diethylstilbestrol in female rats and possessed approximate LD50 values of 400->800 mg/kg.
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Doi:10.1021/jo01124a003
(1955)Doi:10.1021/ja00455a066
(1977)Doi:10.1039/C39720000386
(1972)Doi:10.1016/0006-2952(62)90126-0
()Doi:10.1021/acs.joc.6b03089
(2017)Doi:10.1002/chem.201800648
(2018)
