Journal of Medicinal Chemistry p. 1562 - 1569 (1977)
Update date:2022-08-04
Topics:
DeWald
Lobbestael
Butler
A series of 4-aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4] diazepin-7(1H)-ones was synthesized and screened for psychotropic activity. In animals, a number of these pyrazolodiazepinones had strong CNS effects similar to diazepam. One compound, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8 trimethylpyrazolo[3,4-e][1,4)diazepin-7(1H)-one (54), is being studied in the clinic as a component of a new animal anesthetic Tilazol.
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Doi:10.1071/CH9781011
(1978)Doi:10.1021/jm00209a006
(1978)Doi:10.1021/jo01317a028
(1979)Doi:10.1021/jo00802a018
(1971)Doi:10.1039/j39700001114
(1970)Doi:10.1016/S0022-328X(99)00724-X
(2000)
