Journal of Medicinal Chemistry p. 1267 - 1270 (1987)
Update date:2022-08-04
Topics:
Bettoni, Giancarlo
Loiodice, Fulvio
Tortorella, Vincenzo
Conte-Camerino, Diana
Mambrini, Mercede
et al.
2-(p-Chlorophenoxy)isobutyric acid (clofibric acid (1) or CPIB) is a drug known to block chloride membrane conductance (GCl) in rat striated muscle.In the present study chiral analogues of CPIB (2-(p-chlorophenoxy)propionic acid (2) and 2-(p-chlorophenoxy)butyric acid (3)) have been tested to evaluate the influence of chirality on Cl ion flux in the channel.The results showed that the chloride channel conductance strongly depends on the absolute configuration: in fact, the S-(-) isomers of the tested compounds strongly decreased the GCl of skeletal muscle membrane, whereas the R-(+) isomers were virtually ineffective.These data allow the hypothesis that, like other ion channels present in various biological systems, the chloride channel of skeletal muscle membrane could also have a stereospecific binding site (or receptor) regulating chloride ion flux.
View MoreContact:13357117572
Address:No.149 Shiji dadao Road.
Contact:+86-371-55981030
Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Jining tiansheng chemical co.,ltd.
Contact:+86-537-5158722
Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Contact:13357117572
Address:No.149 Shiji dadao Road.
Doi:10.1016/S0040-4020(01)91308-0
(1984)Doi:10.1039/c0ob00467g
(2011)Doi:10.1039/c5cc00533g
(2015)Doi:10.1021/acs.jmedchem.7b01345
(2018)Doi:10.1007/BF00778014
()Doi:10.1039/P29770001032
(1977)