Tetrahedron p. 7067 - 7080 (1991)
Update date:2022-08-04
Topics:
Dolle
Hetru
Roussel
Rousseau
Sobrio
Luu
Hoffmann
We have synthesized a tritiated form of 14α-hydroxy-5β-cholest-7-ene-3,6-dione (5β-diketol) of high specific activity (1.74 TBq/mmol) from 7-dehydrocholesterol in seven steps with stereoselective introduction of the A/B cis ring junction as the key reaction. We have examined the ability of endocrine glands (prothoracic glands) of Locusta migratoria to use this molecule as a precursor of 3-dehydroecdysone and of ecdysone biosynthesis. A very efficient conversion of 5β-diketol to ecdysone and to 3-dehydroecdysone was monitored, which opens up new possibilities for the understanding of the role of 3-dehydro-compounds in ecdysteroid biosynthesis.
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Doi:10.1039/c39870001301
(1987)Doi:10.1055/s-2007-970742
(2007)Doi:10.1021/ic034928e
(2003)Doi:10.1016/j.phytochem.2021.112674
(2021)Doi:10.1016/S0040-4039(01)83121-X
(1977)Doi:10.1002/ardp.19773100615
(1977)