Tetrahedron p. 7067 - 7080 (1991)
Update date:2022-08-04
Topics:
Dolle
Hetru
Roussel
Rousseau
Sobrio
Luu
Hoffmann
We have synthesized a tritiated form of 14α-hydroxy-5β-cholest-7-ene-3,6-dione (5β-diketol) of high specific activity (1.74 TBq/mmol) from 7-dehydrocholesterol in seven steps with stereoselective introduction of the A/B cis ring junction as the key reaction. We have examined the ability of endocrine glands (prothoracic glands) of Locusta migratoria to use this molecule as a precursor of 3-dehydroecdysone and of ecdysone biosynthesis. A very efficient conversion of 5β-diketol to ecdysone and to 3-dehydroecdysone was monitored, which opens up new possibilities for the understanding of the role of 3-dehydro-compounds in ecdysteroid biosynthesis.
View MoreContact:+65 9658 0999
Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Contact:21-7631221 15884421033
Address:326 Science and technology,Shanghai,China
Oren Hydrocarbons (Qingdao) Co., Ltd.
Contact:+86-532-68607667-801
Address:Room 3 # 302, No.9 Qingyun Road, Qingdao, China
Chengda Pharmaceuticals Co., Ltd.
Contact:+86-573-84601188
Address:hengshan Road 5# in Jiashan, zhejiang
shijiazhuang baisheng chem co.; ltd
Contact:86-0311-80790826
Address:shijiazhuang hebei
Doi:10.1039/c39870001301
(1987)Doi:10.1055/s-2007-970742
(2007)Doi:10.1021/ic034928e
(2003)Doi:10.1016/j.phytochem.2021.112674
(2021)Doi:10.1016/S0040-4039(01)83121-X
(1977)Doi:10.1002/ardp.19773100615
(1977)