Bioorganic and Medicinal Chemistry Letters p. 489 - 493 (2003)
Update date:2022-09-26
Topics:
Wang, Weibo
Li, Qun
Hasvold, Lisa
Steiner, Beth
Dickman, Daniel A.
Ding, Hong
Clairborne, Akyio
Chen, Hui-Ju
Frost, David
Goldman, Robert C.
Marsh, Kennan
Hui, Yu-Hua
Cox, Brian
Nilius, Angela
Balli, Darlene
Lartey, Paul
Plattner, Jacob J.
Bennani, Youssef L.
The echinocandin class of cyclic lipopepetides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.
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