Lipids p. 666 - 668 (1977)
Update date:2022-07-30
Topics:
Hays
Parks
Pierce Jr
Oehlschlager
15-Aza-24-methylene-D-homocholesta-8,14-dien-3β-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthesis in S. cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3β-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the Δ14 sterol reductase.
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Doi:10.1021/ja1028556
(2010)Doi:10.1016/j.tet.2003.09.099
(2003)Doi:10.1016/j.tet.2003.09.100
(2003)Doi:10.1016/j.tet.2003.09.084
(2003)Doi:10.1021/ja00457a032
(1977)Doi:10.1021/ja00462a041
(1977)
