Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators

DOI: 10.1016/j.tet.2006.09.082

Source and publish data:

Tetrahedron p. 12025 - 12040 (2006)

Update date:2022-08-03

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Authors:

Muller, Thierry

Coowar, Djalil

Hanbali, Mazen

Heuschling, Paul

Luu, Bang

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Article abstract of DOI:10.1016/j.tet.2006.09.082

The synthesis of tocopherol fatty alcohols (TFAs), potent microglial activation modulators, was achieved via C-alkylation of trimethylhydroquinone. Several analogs, in particular water-soluble prodrugs, have been synthesized using a Wittig reaction and th

Full text of DOI:10.1016/j.tet.2006.09.082

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