Microbiological enantioselective synthesis of (S) and (R) 4-(p-anisyloxy)-3-hydroxybutyrates as new chiral building blocks for the synthesis of β-lactam antibiotics

Article abstract of DOI:10.1016/S0040-4020(01)89309-1

Both enantiomers of 4-p-anisyloxy-3-hydroxybutanoates 4 have been prepared in high e.e. by reduction of the corresponding β-ketoesters or β-ketocarboxylates with immobilized fermenting baker's yeast. The utility of these new chiral building blocks in the