A highly effective phosphinite ligand derived from D-mannitol for Rh- catalyzed asymmetric hydrogenation

Article abstract of DOI:10.1016/S0040-4039(98)02457-5

A novel chiral phosphinite 1,2,5,6-di-isopropylidene-3, 4- bis(diphenylphosphino)-D-mannitol was prepared and its rhodium complex was found to be an effective catalyst for the asymmetric hydrogenation of amidoacrylic acid and its derivatives with product ee's ranging from 90% to 97%.