Napthalene-catalysed lithiation of carbamoyl and thiocarbamoyl chlorides under Barbier-type reaction conditions

Article abstract of DOI:10.1016/0040-4020(96)00827-7

The reaction of different carbamoyl or thiocarbamoyl chlorides 1 with carbonyl compounds or imines 2 in the presence of an excess of lithium powder and a catalytic amount of naphthalene (3 mol %) in THF at -78°C leads, after hydrolysis with water, to the