Studies of selective Boc removal in the presence of silyl ethers

Article abstract of DOI:10.1016/0040-4039(96)01070-2

The selective removal of N-Boc protection can be obtained in the presence of either TBDMS or TBDPS ethers. On the basis of promising results from the literature, we first tried sonication, that failed, whereas the exclusive cleavage of the Boc group was successfully achieved by a saturated solution of HCl in ethyl acetate.