ENZYME-CATALYZED SYNTHESIS OF (S)-CYANOHYDRINS AND SUBSEQUENT HYDROLYSIS TO (S)-α-HYDROXY-CARBOXYLIC ACIDS

DOI: 10.1016/S0040-4039(00)88777-8

Source and publish data:

Tetrahedron Letters p. 1249 - 1252 (1990)

Update date:2022-08-04

Topics:

Authors:

Effenberger, Franz

Hoersch, Brigitte

Foerster, Siegfried

Ziegler, Thomas

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Article abstract of DOI:10.1016/S0040-4039(00)88777-8

(S)-Cyanohydrins 2 are obtained with high enantioselectivity from aromatic aldehydes and HCN in the presence of (S)-oxynitrilase (E.C.4.1.2.11).Acid-catalyzed hydrolysis of the cyanohydrins 2 affords the corresponding (S)-α-hydroxy carboxylic acids 3 without racemization.

Full text of DOI:10.1016/S0040-4039(00)88777-8

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