Novel modified tripeptide inhibitors of α4β7 mediated lymphoid cell adhesion to MAdCAM-1

DOI: 10.1016/S0960-894X(98)00286-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1601 - 1606 (1998)

Update date:2022-07-31

Topics:

Authors:

Shroff Shroff

Schwender

Baxter Baxter

Brookfield

Payne Payne

Cochran Cochran

Gallant Gallant

Briskin Briskin

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Article abstract of DOI:10.1016/S0960-894X(98)00286-8

MAdCAM-1 specifically binds the lymphocyte integrin α₄β₇ and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/α_4<

Full text of DOI:10.1016/S0960-894X(98)00286-8

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