Journal of Medicinal Chemistry p. 769 - 773 (1978)
Update date:2022-07-30
Topics:
Tucker
Coope
The synthesis is described of a series of derivatives of 1-(aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. These compounds were investigated for their β-adrenoreceptor blocking properties and their selectivity of action for the cardiac β1 receptor. The structure-activity relationships are discussed with particular reference to the effects of the sulfur, sulfoxide, and sulfone groups on β-adrenoreceptor blocking potency and selectivity.
View MoreContact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Anyang Double Circle Auxiliary CO.,LTD
Contact:0086-134 6082 4403
Address:dongfeng road, anyang city, henan province,china
Contact:+86-717-6370352
Address:168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Doi:10.1016/0040-4020(78)80035-0
(1978)Doi:10.1016/S0040-4039(02)02435-8
(2002)Doi:10.1021/jo01028a012
(1964)Doi:10.1021/jo030070z
(2004)Doi:10.1021/jo01351a052
(1961)Doi:10.1016/S0040-4039(01)85417-4
(1978)
