Journal of Medicinal Chemistry p. 769 - 773 (1978)
Update date:2022-07-30
Topics:
Tucker
Coope
The synthesis is described of a series of derivatives of 1-(aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. These compounds were investigated for their β-adrenoreceptor blocking properties and their selectivity of action for the cardiac β1 receptor. The structure-activity relationships are discussed with particular reference to the effects of the sulfur, sulfoxide, and sulfone groups on β-adrenoreceptor blocking potency and selectivity.
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Doi:10.1016/0040-4020(78)80035-0
(1978)Doi:10.1016/S0040-4039(02)02435-8
(2002)Doi:10.1021/jo01028a012
(1964)Doi:10.1021/jo030070z
(2004)Doi:10.1021/jo01351a052
(1961)Doi:10.1016/S0040-4039(01)85417-4
(1978)
