β-Adrenergic blocking agents. 18. 1-(Aryloxy)-3-(arylthioaklylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-ols

Article abstract of DOI:10.1021/jm00206a010

The synthesis is described of a series of derivatives of 1-(aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. These compounds were investigated for their β-adrenoreceptor blocking properties and their selectivity of action for the cardiac β₁ receptor. The structure-activity relationships are discussed with particular reference to the effects of the sulfur, sulfoxide, and sulfone groups on β-adrenoreceptor blocking potency and selectivity.