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diselenides as possible coupling partners.2 To our delight,
diphenyl diselenide led to the desired cross-coupling product 5
in moderate yield (Scheme 3).
Goossen, Angew. Chem. Int. Ed., 2015D, O54I:,1103.110339V0/i.eCw6ACrCtic0le4O48nl6inGe
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In conclusion, we have disclosed the first example of a
copper-catalyzed decarboxylative thiolation of benzoic acids
under aerobic conditions. The broad scope of heteroaromatic
carboxylic acids tolerated by this catalyst system is
unprecedented for oxidative decarboxylative coupling
reactions catalyzed by first-row transition-metals. We have
identified the disulfide to be a key intermediate, yet the nature
of the active catalyst remains unclear. Full mechanistic studies
are underway to reveal the detailed reaction pathway.
We are grateful to the NSF (CHE-1453879) and West Virginia
University for financial support of this work. NMR
spectroscopy facilities were partially supported by the NSF
(CHE-1228336). We thank Prof. Stephen Valentine and Megan
M. Maurer for HRMS analyses.
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21 Similar limitations have been observed in other Cu (see ref.
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4 | J. Name., 2012, 00, 1-3
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