STEREOSELECTIVE SYNTHESIS OF α-RIBONUCLEOSIDES FROM 1-HYDROXY SUGARS BY USING 2-FLUOROPYRIDINIUM TOSYLATE

Article abstract of DOI:10.1246/cl.1984.557

A novel method for the preparation of α-ribonucleosides was developed by the use of 2-fluoro-1-methylpyridinium tosylate as a condensing reagent.Various α-ribonucleosides were synthesized from 1-hydroxy sugars and trimethylsilylated nitrogen compounds, such as nucleoside bases and azide, in good yields under mild conditions.