Journal of Medicinal Chemistry p. 7979 - 7991 (2010)
Update date:2022-08-03
Topics:
Gibbs, Alan C.
Abad, Marta C.
Zhang, Xuqing
Tounge, Brett A.
Lewandowski, Francis A.
Struble, Geoffrey T.
Sun, Weimei
Sui, Zhihua
Kuo, Lawrence C.
A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of three iterations of design, synthesis, and X-ray crystallographic screening to progress low molecula
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