A new spacer group derived from arylmalonaldehydes for glucuronylated prodrugs

DOI: 10.1016/S0960-894X(98)00454-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2545 - 2548 (1998)

Update date:2022-08-03

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Authors:

Papot, Sebastien

Combaud, Damien

Gesson, Jean-Pierre

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Article abstract of DOI:10.1016/S0960-894X(98)00454-5

A new glucuronylated prodrug of doxorubicin, potentially useful for ADEPT or PMT cancer chemotherapy, has been prepared from 4-methyl phenyl malonaldehyde. The enol ether spacer, linked via a carbamate to the 3'-amino group of doxorubicin is rapidly cleav

Full text of DOI:10.1016/S0960-894X(98)00454-5

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