A new spacer group derived from arylmalonaldehydes for glucuronylated prodrugs

DOI: 10.1016/S0960-894X(98)00454-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2545 - 2548 (1998)

Update date:2022-08-03

Topics:

Authors:

Papot, Sebastien

Combaud, Damien

Gesson, Jean-Pierre

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00454-5

A new glucuronylated prodrug of doxorubicin, potentially useful for ADEPT or PMT cancer chemotherapy, has been prepared from 4-methyl phenyl malonaldehyde. The enol ether spacer, linked via a carbamate to the 3'-amino group of doxorubicin is rapidly cleav

Full text of DOI:10.1016/S0960-894X(98)00454-5

Products guided by the article

Product name:methyl 2,3,4-tri-O-acetyl-(2'-(4''-methylphenyl)-3'-oxo-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate

Cas No:676606-03-4

R&D Labs maybe for 676606-03-4

Jiangxi Hessence Chemicals Co., Ltd.

Contact:+86 796 3511924

Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
Anhui Biochem United Pharmaceutical Co., Ltd.

Contact:0086 551 5167062 / 5228268

Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Shanghai Pinewood Fine Chemical Co., Ltd.

website:http://www.pinewoodchem.com

Contact:0086-21-62417129，62414096

Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
Tianjin Ingenochem Technology Co.,Ltd

Contact:+86-22-23677060

Address:Hitech Green Industry Park K2-9-602, Nankai district
Hebei Maison Chemical Co.,Ltd

website:http://www.maisonchem.com.cn

Contact:0086-311-83833777

Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,

Relevant to this article

Transition metal complexes with pyrazole-based ligands Part 12. Characterisation and thermal decomposition of CuCl₂ complexes with di- and trisubstituted pyrazoles

Doi:10.1023/A:1013133405261
(2001)
Synthesis of the Salmonella type E(1) core trisaccharide as a probe for the generality of 1-(benzenesulfinyl)piperidine/triflic anhydride combination for glycosidic bond formation from thioglycosides.

Doi:10.1021/jo0108818
(2002)
Synthesis of chiral organotin reagents: Synthesis of bicyclo[2.2.1]heptan-2-yl(diphenyl)tin hydrides with cis-disposed, oxygen-containing substituents

Doi:10.1039/a706295h
(1998)
Spiroiminodihydantoin is a major product in the photooxidation of 2′-deoxyguanosine by the triplet states and oxyl radicals generated from hydroxyacetophenone photolysis and dioxetane thermolysis

Doi:10.1021/ol017138m
(2002)
Synthesis of zigzag-chain and cyclic-octanuclear calcium complexes and hexanuclear bulky aryl-phosphate sodium complexes with ortho-amide groups: Structural transformation involving a network of inter- and intramolecular hydrogen bonds

Doi:10.1021/ja011457r
(2002)
Doi:10.1021/jo01022a025
(1965)

Article Doi