Organic Letters p. 7693 - 7697 (2021)
Update date:2022-08-05
Topics:
Argade, Malaika D.
Straub, Carolyn J.
Rusali, Lisa E.
Santarsiero, Bernard D.
Riley, Andrew P.
The first synthesis of aristoquinoline (1), a naturally occurring nicotinic acetylcholine receptor (nAChR) antagonist, was accomplished using two different approaches. Comparison of the synthetic material's spectroscopic data to that of the isolated alkaloid identified a previously misassigned stereogenic center. An evaluation of each enantiomer's activity at the α3β4 nAChR revealed that (+)-1 is significantly more potent than (-)-1. This unexpected finding suggests that naturally occurring 1 possesses the opposite absolute configuration from indole-containing Aristotelia alkaloids.
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Doi:10.1002/chem.200305492
(2004)Doi:10.1246/bcsj.53.2634
(1980)Doi:10.1039/b311799e
(2003)Doi:10.1246/cl.1978.979
(1978)Doi:10.1016/j.poly.2014.12.023
(2015)Doi:10.1016/j.bmcl.2003.12.064
(2004)