Bioorganic and Medicinal Chemistry Letters p. 983 - 987 (2004)
Update date:2022-08-05
Topics:
Zhang, Penglie
Bao, Liang
Zuckett, Jingmei F.
Goldman, Erick A.
Jia, Zhaozhong J.
Arfsten, Ann
Edwards, Susan
Sinha, Uma
Hutchaleelaha, Athiwat
Park, Gary
Lambing, Joseph L.
Hollenbach, Stanley J.
Scarborough, Robert M.
Zhu, Bing-Yan
Anthranilamides 4 and 5 were designed and synthesized as selective and orally bioavailable factor Xa inhibitors. Structural modifications aimed at lowering their lipophilicity were performed at the central phenyl ring and at the S4 binding biphenyl region by incorporating water solublizing substituents. The resulting compounds (e.g., 7, 8, 14, 30a, and 32b) are highly potent in vitro, and show improved activity in human plasma-based thrombin generation assay.
View MoreNanJing KaiHeng Chemical CO., LTD.
Contact:+86-25-85768391
Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Taixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Henan Blight Industry Co., Ltd
Contact:13203734935 371-8284635
Address:ZhengzhouHuayuan Road
Cangzhou Bao Lai Da Import&Export Trading Co.,Ltd
Contact:86-317-2096605
Address:Cangzhou City,HeBei Province,China
Doi:10.1246/bcsj.51.2415
(1978)Doi:10.1107/S0108270100002729
(2000)Doi:10.1007/BF00504194
(1985)Doi:10.1021/ol502578h
(2014)Doi:10.1055/s-2004-815929
(2004)Doi:10.1021/jo035482m
(2004)