Analogs of 1α,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs

DOI: 10.1016/j.bmc.2006.02.015

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4645 - 4656 (2006)

Update date:2022-08-02

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Authors:

Shimazaki, Mika

Miyamoto, Yukiko

Yamamoto, Keiko

Yamada, Sachiko

Takami, Masamichi

Shinki, Toshimasa

Udagawa, Nobuyuki

Shimizu, Masato

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Article abstract of DOI:10.1016/j.bmc.2006.02.015

In our previous papers, we found that introduction of a substituent at C(2) into 1α,25-dihydroxy-19-norvitamin D₃ (2a) caused dramatic changes in binding affinity for the vitamin D receptor (VDR) and in transcriptional activity compared with th

Full text of DOI:10.1016/j.bmc.2006.02.015

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