ASYMMETRIC ALDOL REACTION OF α-ISOCYANOACETAMIDES WITH ALDEHYDES CATALYZED BY A CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEX

DOI: 10.1016/S0040-4039(00)82336-9

Source and publish data:

Tetrahedron Letters p. 6321 - 6324 (1988)

Update date:2022-08-05

Topics:

Authors:

Ito, Yoshihiko

Sawamura, Masaya

Kobayashi,Masaaki

Hayashi, Tamio

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Article abstract of DOI:10.1016/S0040-4039(00)82336-9

Aldol reaction of N,N-dialkyl-α-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-1 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio- and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6percent ee, which were converted into optically active threo-β-hydroxyamino acids.

Full text of DOI:10.1016/S0040-4039(00)82336-9

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