Chemistry of Natural Compounds p. 176 - 178 (1981)
Update date:2022-08-04
Topics:
Mikhano, S. D.
Kulachkina, N. S.
Filippova, T. M.
Suchkova, I. G.
Berezovskii, V. M.
(+-)-Biotin has been synthesized from a mixture of cis- and allo-trisubstituted dehydrothiophanes by a scheme providing for the easy elimination of the accompanying allo-substituted thiophane in the form of an intermediate and not as the final isomeric allo-biotin.The imidazoline ring of biotin is formed from a dialkoxycarbonyldiaminothiophane under the conditions of partial hydrolysis of one of the protective groups with the elimination of phosgene from the scheme of synthesis.
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