A bicyclic ketone as a solid-state 13C NMR intensity reference

Article abstract of DOI:10.1021/ac00053a009

The synthesis and NMR relaxation properties of 4-(N-methylpyrrolidino)bicyclo[3.2.1]octan-8-one triflate (321) are described. The use of ¹³CO-enriched 321 as a ¹³C intensity reference is justified and demonstrated. The dominant ¹³C peak in 321-¹³CO is 217 ppm, far from most other ¹³C chemical shifts of diamagnetic organic compounds. Hence, this intensity reference peak avoids peak overlap problems for most organic compounds.