5-fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils

DOI: 10.1248/cpb.45.1372

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1372 - 1375 (1997)

Update date:2022-09-26

Topics:

Authors:

Ozaki, Shoichiro

Kong, Xiangzheng

Watanabe, Yutaka

Hoshiko, Tomonori

Koga, Toshikazu

Ogasawara, Tomio

Takizawa, Tsuneharu

Fujisawa, Hiroshi

Iigo, Masaaki

Hoshi, Akio

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Article abstract of DOI:10.1248/cpb.45.1372

Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5- fluorouracil and isocyanate or amine. Antitumor activity was tested in the L- 1210 tumor system and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil). 1-(4- Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.

Full text of DOI:10.1248/cpb.45.1372

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