Bioorganic and Medicinal Chemistry Letters p. 2227 - 2230 (2003)
Update date:2022-08-05
Topics:
Kim, Hye Yeon
Lee, Jae Seok
Cha, Joo Hwan
Pae, Ae Nim
Cho, Yong Seo
Chang, Moon Ho
Koh, Hun Yeong
We have prepared and evaluated the antibacterial activities of a series of substituted methylenepiperidinyl and methylenepyrrolidinyl oxazolidinones against several gram-positive strains including the resistant strains of Staphyloccus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed comparable or superior in vitro activities (MIC) to vancomycin.
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