Unnatural nucleosides and nucleotides. III. Preparation of 2-14C and 4-14C labelled 5-alkyluracils and 5-alkyl-2'-deoxyuridines

Article abstract of DOI:10.1002/jlcr.2580140509

2-¹⁴C Labelled 5-alkyluracils were prepared by condensation of the diethylacetals of α-formyl-carbonic acid esters with ¹⁴C-thiourea. Compounds labelled at 4-C were synthesized by condensation of the labelled carboxylic acid derivatives with thiourea. β-Anomers of 5-alkyl-2'-deoxyuridines were obtained in a fairly good radiochemical yield. Alkyl substituents ranged from methyl to tetradecyl, isopropyl and tert-butyl.