Lipase catalysed resolution of (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols: Useful intermediates for the synthesis of optically-active γ-lactones

Article abstract of DOI:10.1016/S0957-4166(96)00475-2

Various (R)-and (S)-1-trimethylsilyl-1-alkyn-3-ols; chiral building units useful for the synthesis of biologically active compounds, have been efficiently resolved by enantioselective acetylation mediated by immobilized lipase PS. The resolution is applied to the synthesis of (R)- and (S)-5-octyl-2-(5H)-furanones.