Direct organocatalytic asymmetric mannich addition of 3-substituted-2H-1,4- benzoxazines: Access to tetrasubstituted carbon stereocenters

Article abstract of DOI:10.1002/adsc.201300654

3-Substituted-2H-1,4-benzoxazines undergo a highly enantioselective direct Mannich reaction with acetone in the presence of an L-proline catalyst at room temperature. The corresponding N-heterocycles with α-tetrasubstituted carbon stereocenters were obtai