Bioorganic and Medicinal Chemistry Letters p. 1093 - 1096 (1998)
Update date:2022-08-03
Topics:
Schlachter, Stephen T.
Galinet, Louise A.
Shields, Sharon K.
Aspar, Danielle G.
Dunn, Colin J.
Staite, Nigel D.
Nugent, Richard A.
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti-inflammatory effects.
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