Inhibition of monoamine oxidase-b by 5H-indeno[1,2-c]pyridazines: Biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs

DOI: 10.1021/jm00019a018

Source and publish data:

Journal of Medicinal Chemistry p. 3874 - 3883 (1995)

Update date:2022-07-29

Topics:

Authors:

Kneubuhler

Thull Thull

Altomare

Carta Carta

Gaillard

Carrupt -

Carotti Carotti

Testa Testa

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Article abstract of DOI:10.1021/jm00019a018

A large series (66 compounds) of indeno[1,2-c]pyridazin-5-ones (IPs) were synthesized and tested on their monoamine oxidase-A (MAO-A) and MAO-B inhibitory activity. All of the tested compounds acted preferentially on MAO- B displaying weak (nonmeasurable

Full text of DOI:10.1021/jm00019a018

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