Pyrimidine Derivatives. 4. Synthesis and Antihypertensive Activity of 4-Amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline Derivatives

DOI: 10.1021/jm00357a016

Source and publish data:

Journal of Medicinal Chemistry p. 411 - 416 (1983)

Update date:2022-08-05

Topics:

Authors:

Sekiya, Tetsuo

Hiranuma, Hidetoshi

Hata, Shunsuke

Mizogami, Susumu

Hanazuka, Mitsuo

Yamada, Shun-ichi

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Article abstract of DOI:10.1021/jm00357a016

A series of 30 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline derivatives was prepared and tested for their ability to reduce blood pressure in conscious, spontaneously hypertensive rats (SHR).A number of these compounds, notably 4-amino-2-(4-

Full text of DOI:10.1021/jm00357a016

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