Bioorganic and Medicinal Chemistry Letters p. 2587 - 2590 (2003)
Update date:2022-08-05
Topics:
Das, Jagabandhu
Moquin, Robert V.
Lin, James
Liu, Chunjian
Doweyko, Arthur M.
DeFex, Henry F.
Fang, Qiong
Pang, Suhong
Pitt, Sidney
Shen, Ding Ren
Schieven, Gary L.
Barrish, Joel C.
Wityak, John
A series of structurally novel benzothiazole based small molecule inhibitors of p56lck was prepared to elucidate their structure-activity relationships (SAR), selectivity and cell activity in the T-cell proliferation assay. BMS-350751 (2) and BMS-358233 (3) are identified as potent Lck inhibitors with excellent cellular activities against T-cell proliferation.
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Doi:10.3987/COM-92-5999
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