Journal of Organic Chemistry p. 1367 - 1371 (1988)
Update date:2022-08-03
Topics:
Trecourt, F.
Mallet, M.
Marsais, F.
Queguiner, G.
Directed ortho lithiation of 2-methoxypyridine (1) has been regioselectively achieved at position 3 by using methyllithium catalyzed by a small amount of diisopropylamine.This metalation methodology, called "catalyzed metalation", gave good results whereas other metalation routes failed.This allowed the convenient synthesis of various 3-substituted 2-methoxypyridines of general interest.
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