Journal of Pharmaceutical Sciences p. 591 - 595 (1979)
Update date:2022-09-26
Topics:
Foye
Tovivich
A series of heterocyclic analogs of amphetamine was synthesized. The heterocycles employed included the 2-furyl, 2-thienyl, 3-methyl-2 thienyl, 3-pyridyl, and 6-methyl-2-pyridyl rings. The aliphatic amine group was converted to the N-methylthiourea, dithiocarbamate, methanesulfonyl, trifluoromethanesulfonyl, and trifluoroacetyl functions since similar conversions of the β-phenethylamine structure had shown blood pressure-lowering effects and some loss of behavioral effects. P-Chlorophenyl and 1-naphthyl analogs were also converted to these derivatives. Behavioral and other biological effects, including antiarthritic, passive cutaneous anaphylactic, and antimicrobial, were observed. The 3-methyl-2-thienyl analog of amphetamine significantly increased papillary muscle contractile force without producing arrhythmias.
View Moreshanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011,13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Contact:0091-265-2313036
Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA
Zhejiang Kaili Industrial Co., Ltd
Contact:+86-571-85241926
Address:lantian business center,No.18 Moganshan Road
Contact:13357117572
Address:No.149 Shiji dadao Road.
Doi:10.1021/acs.orglett.5b03519
(2016)Doi:10.1246/bcsj.55.873
(1982)Doi:10.1134/S1070427219090052
(2019)Doi:10.1246/bcsj.52.796
(1979)Doi:10.1021/acs.inorgchem.9b01530
(2019)Doi:10.1007/BF01960325
(1979)