Journal of Medicinal Chemistry p. 1996 - 2000 (1994)
Update date:2022-08-04
Topics:
Chen
Liston
Nielsen
Chapin
Dunaiskis
Hedberg
Ives
Johnson Jr.
Jones
The synthesis of a series of alkylcarbamates of 1,5-methano-2,3,4,5- tetrahydro-1H-2-benzazepin-7-ol is reported. Many of these compounds are potent acetylcholinesterase (AChE) inhibitors. The in vitro AChE inhibition, cholinergic effects, acute toxicity, and elevation of brain acetylcholine levels in vivo of this series of compounds are described. A representative compound, 1d (5.6 mg/kg, po), was able to reverse hemicolinium-3-induced amnesia in the mouse passive avoidance assay.
View MoreNanjing Xi Ze Biological Technology Co., Ltd
Contact:86-025-66023220
Address:Address: Nanjin Qixia District Maigaoqiao R & D base in Pioneer Park Chun Yin Road 18-A928
Jiangsu Feymer Technology Co., Ltd.
Contact:+86-512-58110132
Address:Fenghuang Town, Zhangjiagang City, Jiangsu Province, China
NINGXIA DARONG CHEMICALS & METALLURGY CO.,LTD.
Contact:86-952-2179751
Address:Darong Road, Dawukou, Shizuishan, Ningxia 753001, China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Contact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
Doi:10.1021/acs.jced.7b01053
(2018)Doi:10.1021/jf072394k
(2008)Doi:10.1016/j.tetlet.2003.09.106
(2003)Doi:10.1021/acs.orglett.7b02170
(2017)Doi:10.1016/j.molstruc.2019.127447
(2020)Doi:10.1016/j.molcatb.2014.02.008
(2014)