Journal of Medicinal Chemistry p. 1996 - 2000 (1994)
Update date:2022-08-04
Topics:
Chen
Liston
Nielsen
Chapin
Dunaiskis
Hedberg
Ives
Johnson Jr.
Jones
The synthesis of a series of alkylcarbamates of 1,5-methano-2,3,4,5- tetrahydro-1H-2-benzazepin-7-ol is reported. Many of these compounds are potent acetylcholinesterase (AChE) inhibitors. The in vitro AChE inhibition, cholinergic effects, acute toxicity, and elevation of brain acetylcholine levels in vivo of this series of compounds are described. A representative compound, 1d (5.6 mg/kg, po), was able to reverse hemicolinium-3-induced amnesia in the mouse passive avoidance assay.
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