Bioorganic and Medicinal Chemistry Letters p. 267 - 270 (2006)
Update date:2022-08-04
Topics:
Leban, Johann
Kralik, Martin
Mies, Jan
Baumgartner, Roland
Gassen, Michael
Tasler, Stefan
A previously discovered DHODH inhibitor series was further improved by replacing the cyclopentene ring by aromatic heterocycles. Different isomers of these compounds were prepared by the directed ortho-metallation procedure. The compounds are more active than the corresponding cyclopentene analogs and show potent effects on PBMC's proliferation.
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