Journal of the Chemical Society. Perkin transactions I p. 2316 - 2321 (1980)
Update date:2022-08-05
Topics:
Cusack, Noel J.
Shaw, Gordon
Logemann, Fatma I.
Ethyl and benzyl 5-amino-1-(2-pyridyl)imidazole-4-carboxylates, obtained from ethyl or benzyl α-amino-α-cyanoacetate, respectively, and ethyl formimidate hydrochloride followed by 2-aminopyridine, were converted into 5-amino-1-(2-pyridyl)imidazole-4-carboxylic acid which was decarboxylated in situ to 5-amino-1-(2-pyridyl)imidazole.Reaction of 2-N-formylamino-N-(2-pyridyl)acetamide with ammonia and ammonium chloride gave 5-aminoimidazole and a similar reaction with the nucleotide 2-N-formylglicineamide ribotide similarly gave evidence for aminoimidazole formation. 4-Cyano-5- imidazolone, prepared by reaction of 2-cyano-N-formylacetamide with nitrous acid and reduction of the hydroxyimino derivative so produced, with ammonia and ammonium sulphite at 100 deg C, gave 5-aminoimidazole-4-carboxamide.Implications of the reactions involved are discussed.
View MoreChemsigma International Co.,Ltd.
website:http://www.chemsigma.com
Contact:86-025-58748998
Address:Rm.705, 15th Building,Rd.Xinke II
Contact:86-21-34622192，13917187091，21-34622765
Address:No. 500 Caobao Road Shanghai P.R China
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.
Contact:+86-(574)-81110986
Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Ningbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
Doi:10.1007/BF00561343
(1980)Doi:10.1021/ja00766a016
(1972)Doi:10.1002/jhet.3585
(2019)Doi:10.1016/S0040-4039(01)85029-2
(1972)Doi:10.1016/S0022-1139(01)00430-4
(2001)Doi:10.1016/S0040-4039(01)01399-5
(2001)
