Journal of the Chemical Society. Perkin transactions I p. 2316 - 2321 (1980)
Update date:2022-08-05
Topics:
Cusack, Noel J.
Shaw, Gordon
Logemann, Fatma I.
Ethyl and benzyl 5-amino-1-(2-pyridyl)imidazole-4-carboxylates, obtained from ethyl or benzyl α-amino-α-cyanoacetate, respectively, and ethyl formimidate hydrochloride followed by 2-aminopyridine, were converted into 5-amino-1-(2-pyridyl)imidazole-4-carboxylic acid which was decarboxylated in situ to 5-amino-1-(2-pyridyl)imidazole.Reaction of 2-N-formylamino-N-(2-pyridyl)acetamide with ammonia and ammonium chloride gave 5-aminoimidazole and a similar reaction with the nucleotide 2-N-formylglicineamide ribotide similarly gave evidence for aminoimidazole formation. 4-Cyano-5- imidazolone, prepared by reaction of 2-cyano-N-formylacetamide with nitrous acid and reduction of the hydroxyimino derivative so produced, with ammonia and ammonium sulphite at 100 deg C, gave 5-aminoimidazole-4-carboxamide.Implications of the reactions involved are discussed.
View MoreContact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
Taizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Shanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
Suzhou HeChuang Chemical Co.,Ltd.
Contact:+86-512-88800520
Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Contact:17316303296
Address:240 Amboy Ave
Doi:10.1007/BF00561343
(1980)Doi:10.1021/ja00766a016
(1972)Doi:10.1002/jhet.3585
(2019)Doi:10.1016/S0040-4039(01)85029-2
(1972)Doi:10.1016/S0022-1139(01)00430-4
(2001)Doi:10.1016/S0040-4039(01)01399-5
(2001)
