Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(Alkylamino)uracils

Article abstract of DOI:10.1021/jm00175a007

Substituted 6-anilinouracils were found to be potent inhibitors of the replication-specific enzyme, DNA polymerase III, from Bacillus subtilis. Inhibition potency was maximized by inclusion of small alkyl groups or halogens in the meta and para positions