Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9- deazapurine and related compounds

DOI: 10.1016/j.bmc.2004.04.003

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3187 - 3195 (2004)

Update date:2022-08-05

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Authors:

Otmar, Miroslav

Masojidkova, Milena

Votruba, Ivan

Holy, Antonin

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Article abstract of DOI:10.1016/j.bmc.2004.04.003

Treatment of 6-bromomethyl- or 6-dibromomethyl-5-nitropyrimidine-2,4- diamine with KCN gave the same product - (2,6-diamino-5-nitropyrimidinyl) acetonitrile. Benzylation of the nitrile took place on the α-carbon to the cyano group preferentially affording

Full text of DOI:10.1016/j.bmc.2004.04.003

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