Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C

Article abstract of DOI:10.1016/j.bmcl.2004.04.028

Phosphinic tripeptide analogues Gly-Xaaψ[P(O)(OH)CH₂]-Gly have been developed as inhibitors of cathepsin C (DPP I), a lysosomal, papain-like cysteine protease. The target compounds were synthesised by addition of methyl acrylate to the appropri