Studies on the Syntheses of Heterocyclic Compounds. 800. A Formal Total Synthesis of (+/-)-Thienamycin and (+/-)-Decysteaminylthienamycin Derivative

DOI: 10.1021/ja00526a048

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Journal of the American Chemical Society p. 2060 - 2065 (1980)

Update date:2022-08-05

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Authors:

Kametani, Tetsuji

Huang, Shyh-Pyng

Yokohama, Shuichi

Suzuki, Yukio

Ihara, Masataka

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Article abstract of DOI:10.1021/ja00526a048

The synthesis of a key intermediate for the preparation of (+/-)-thienamycin (1) and its derivatives has been developed.By 1,3-dipolar cycloaddition, the nitrile oxide derived from 3-nitropropanal dimethyl acetal (3) was added to methyl crotonate to give

Full text of DOI:10.1021/ja00526a048

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