Synthesis of 5--2'-deoxyuridine, the Corresponding Sulfoxide and Sulfone, and Their 5'-Phosphates: Antiviral Effects and Thymidylate Synthetase Inhibition

DOI: 10.1021/jm00177a008

Source and publish data:

Journal of Medicinal Chemistry p. 252 - 256 (1980)

Update date:2022-08-04

Topics:

Authors:

Schmidt, Charles L.

Chang, Charles T.-C.

Clercq, Erik De

Descamps, Johan

Mertes, Mathias P.

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Article abstract of DOI:10.1021/jm00177a008

Substitution on the α position of thymidine with methylthio (3) and methylsylfonyl (5) groups gave antiviral agents that were specific and relatively nontoxic inhibitors of herpes simplex virus replication in cell culture.The thioether (3) was effective a

Full text of DOI:10.1021/jm00177a008

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