Journal of Organic Chemistry p. 999 - 1003 (1980)
Update date:2022-08-04
Topics:
Houminer, Yoram
Several substituted 2-(2-hydroxy-2-arylethyl)pyrazines (1-10) have been prepared and their thermolysis in diglyme and DMF studied.Each of these substrates decomposes to give the parent methylpyrazine and the corresponding aryl aldehyde.Kinetic, isotope effect, and solvent effect studies suggest a mechanism involving a nonpolar concerted six-membered-ring transition state.The degree of proton transfer in the transition state is discussed in detail.Methyl substituents on the pyrazine ring were found to strongly affect the reaction rate.This phenomenon is analyzed interms of the steric and electronic effects induced by the methyl substituents.
View MorePuyang Willing Chemicals Co.,Ltd.
Contact:86-393-4840366
Address:Puyang Henan China
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Shanghai Haoyuan Chemexpress Co., Ltd.
website:https://www.chemexpress.com/
Contact:86-21-58950125
Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
Quzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
Doi:10.1021/jm00138a013
(1981)Doi:10.1021/jm00178a008
(1980)Doi:10.1016/0022-328X(95)00331-J
(1995)Doi:10.1016/0022-328X(93)83319-Q
(1993)Doi:10.1055/s-2004-834863
(2005)Doi:10.1021/ja01202a003
(1947)
